ea0041oc14.2 | Thyroid Cancer | ECE2016
Arts Rob
, Plantinga Theo
, Heinhuis Bas
, Tuit Sander
, Petrulea Mirela
, Tesselaar Marika
, Sloot Yvette
, Kusters Benno
, Joosten Leo
, Georgescu Carmen
, Smit Johannes
, Netea Mihai
, Schulze Joakim
, Netea-Maier Romana
Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...